Treatment for asia syndrome and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant Oct 17, 2024 · This narrative review aims to provide an overview of the ASIA syndrome with a special focus on the role of adjuvants in different vaccines, especially after the COVID-19 pandemic, and insights into development of new treatments. Dec 2, 2024 · Complete cure of ASIA syndrome (Autoimmune/inflammatory Syndrome Induced by Adjuvants) is possible, but it depends on many factors, including the severity of the condition, the duration of the disease, the degree of tissue and organ damage, as well as individual characteristics of the body. Accordingly, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the effectiveness of RBM for DED treatment. Patients must show, at least, 2 major criteria or 1 major and 2 minor criteria. ASIA can be induced by breast implants, polypropylene meshes, and Essure sterilization devices. May 30, 2022 · ASIA syndrome or autoimmune/autoinflammatory syndrome induced by adjuvants results from an immune response to foreign substances. Jul 15, 2024 · Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld's syndrome, is an emerging clinical entity characterized by a diverse array of autoimmune manifestations triggered by adjuvants. Introduction Feb 15, 2023 · Autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome) encompasses non-specific symptoms that occur following exposure to inert material (e. They belong, indeed, to a category of chemical compounds derived from petroleum, including lubricating base oils and highly refined base oils, able to directly elicit the innate immune system via pattern recognition molecules and to indirectly foster the activation of the adaptive immune Oct 12, 2020 · Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. May 27, 2024 · M J C A M Gielen, K L C van Rest, N D Bouvy, G A van Koeveringe, C R Kowalik, J P W R Roovers, R M H Roumen, M C Slot, H P J Willems, W A R Zwaans, AUTOIMMUNE/AUTOINFLAMMATORY SYNDROME INDUCED BY ADJUVANTS (ASIA SYNDROME) AFTER POLYPROPYLENE MESH IMPLANTATION – PROTOCOL OF A PILOT STUDY FOR DIAGNOSTICS AND TREATMENT, British Journal of Surgery, Volume 111, Issue Supplement_5, May 2024 Sep 14, 2016 · Several clinical pictures described by different authors associate the presence of silicone in the body as the triggering substance, as for example the ASIA syndrome (induced by adjuvants) or a variety of Still disease. [Google Scholar] 3. Revisión sistemática de la literatura utilizando las bases de datos PubMed, SciELO, Scopus y Web of Science, siguien-do la guía de PRISMA P y JBI. This treatment is ongoing. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld’s syndrome, encompasses several autoimmune conditions/phenomena that are induced following the exposure to substances with adjuvant activity. Autoimmune/auto-inflammatory syndrome induced by adjuvant (ASIA) or Shoenfeld’s syndrome is a recently described disorder that includes a large group of similar symptoms emerging after the use of external substances [Citation 1]. In addition to a genetic component, there is a risk of development of an undifferentiated Feb 20, 2021 · 1. We'll explain it to you here. In ASIA, autoantibodies directed against G-protein coupled receptors (GPCRs) are associated with dysautonomia. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld’s syndrome, encompasses several autoimmune conditions/phenomena that are induced following the exposure Description. The major criteria for diagnosing ASIA syndrome include: Exposure May 5, 2023 · In the case of ASIA syndrome, there are no experimental studies that compare head to head with optimal methodological design, medical treatment versus treatment by semi-invasive or non-invasive procedures, and in turn, against wide resection and open extraction surgery, which is the current proposal. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/shoenfeld’s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry. 1 Shoenfeld and Agmon-Levin 2 defined a set of major and minor criteria to diagnose ASIA (Table 1). The patient left the hospital on oral steroids (methylprednisone) in high dose, which gradually were tapered to 8 mg methylprednisone daily. Since the recognition of ASIA syndrome, more than 4400 documented cases have been reported so far, illustrated by heterogeneous Oct 17, 2024 · The manuscript is a review on adjuvant-induced autoimmune/inflammatory syndrome (ASIA), a condition also known as Shoenfeld Syndrome that was first described in 2011 by Yehuda Shoelfeld in genetically predisposed individuals exposed to compounds such as silicone, drugs, metals, and vaccine adjuvants. Nov 30, 2024 · Common symptoms linked to ASIA syndrome are chronic fatigue, muscle weakness, and memory loss. Diagnosing ASIA syndrome involves specific tests like blood tests for IgG levels and imaging studies. It is speculated that the migration pathways of Mar 7, 2023 · ASIA is characterized by an innate and adaptive immune response following the exposure to an adjuvant and it includes five conditions namely siliconosis, macrophagic myofasciitis syndrome, sick building syndrome, Gulf War syndrome, and vaccination-induced autoimmunity . Introduction. Material y método. However, SAT following vaccine for SARS-CoV-2 is rare. Apr 4, 2022 · Introduction: Adjuvant-Induced Autoimmune / Auto-inflammatory Syndrome (ASIA) is an immune-mediated condition by the exposure of material previously considered inert, such as silicone, aluminum salts, mineral oils, hyaluronic acid and metallic implants. silicone, aluminum salts), which are thought to trigger an abnormal autoimmune response 1-3. It is necessary to identify the risk factors for ASIA syndrome to understand its pathophysiology and make a timely diagnosis. May 1, 2023 · Small fiber neuropathy is an important clinical manifestation of ASIA. Asociada a Implantes Mamarios como parte del Síndrome de ASIA. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant agent exposure. Diagnosis Jul 1, 2024 · ASIA syndrome classification criteria require validation in various populations before being applied to select patients for clinical studies. Early diagnosis and treatment of ASIA syndrome are crucial for managing the condition effectively and preventing complications. It results from an exaggerated immune response triggered by the adjuvant. Jul 3, 2023 · Introduction. Nov 8, 2023 · Introducción: El síndrome autoinmune/inflamatorio inducido por adyuvantes (ASIA) comprende un espectro de manifestaciones clínicas asociadas con la exposición a distintos adyuvantes, los There is no treatment guideline indicating the process to follow once a patient is considered to meet the criteria for ASIA or a treatment guideline that can be applied to patients with severe compromise due to mechanical complications produced by the migration of the allogenic material 11, 12. In one study, lupus patients were found to have no increase in exacerbations after receiving a hepatitis B vaccine containing an aluminum adjuvant. Siliconosis: Autoimmune/Inflamatory Syndrome Induced by Adjuvants (ASIA). The authors identified two studies refuting the claim for autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) as suggested by Shoenfeld and co-workers. Major Criteria. The role of various environmental factors in the pathogenesis of immune mediated diseases is well established. Nevertheless, the therapeutic efficacy of topical RBM for dry eye disease (DED) treatment remains inconclusive. Herein, we report the case of a 47-year-old female who presented with fever and neck pain for 2 weeks following the first dose of the ChAdOx1 nCoV-19 (Astra Zeneca) vaccine. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a recently identified condition in which the exposure to an adjuvant leads to an aberrant autoimmune response. The present review is aimed at focusing on the "endocrine pebbles" of the mosaic of autoimmunity and of the ASIA syndrome, collecting together 54 cases of sub-acute thyroiditis, 2 cases of Hashimoto's thyroiditis, 11 cases of primary ovarian failure/primary ovarian insufficiency, 13 cases of autoimmune diabetes type 1, and 1 case of autoimmune Oct 17, 2024 · This narrative review aims to provide an overview of the ASIA syndrome with a special focus on the role of adjuvants in different vaccines, especially after the COVID-19 pandemic, and insights into development of new treatments. Autoimmune syndrome induced by adjuvants (ASIA) is an autoimmune syndrome that characterizes many of these cases. SAT is a common thyroid-related syndrome in COVID-19 []. Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) corresponds to a spectrum of immune-mediated diseases triggered by chronic exposure to adjuvants which are substances meant to enhance antigen-specific immune response. The ASIA syndrome was described for the first time by Schoenfeld in 2011. Criteria for ASIA syndrome is definitely met for this patient. 1 Shoenfeld and Agmon-Levin 2 defined a set of major and minor criteria to diagnose ASIA . This narrative review aims to provide an overview of the ASIA syndrome with a special focus on the role of adjuvants in different vaccines, especially after the COVID-19 pandemic, and insights into development of new treatments. S. ASIA syndrome classification criteria require validation in various populations before being applied to select patients for clinical studies. ASIA syndrome is an acronym for a specific autoimmune syndrome. Patients may also experience skin rashes and swollen lymph nodes. 1. Nov 28, 2023 · More than a decade has passed since the initial description of ASIA syndrome and new cases of ASIA have been described and new adjuvants added, they may be associated with the development of ASIA syndrome after the injection of bioimplants for aesthetic purposes, such as hyaluronic acid, methacrylate, polyacrylamide, polyalkylimide and metals The syndrome of ASIA consists of a collection of 5 syndromes: macrophagic myofasciitis syndrome, sick building syndrome, Gulf War syndrome, siliconosis, and vaccination-induced autoimmunity . Feb 19, 2017 · Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA) is a relatively new entity introduced in 2011. Affiliations 1 Division of Rheumatology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada; School for Mental Health and Neurosciences (MHeNs), Maastricht University, Maastricht, the Netherlands. However, the evidence is still debated on the relationship between adjuvants and autoimmune clinical manifestations. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. Recently, reports have suggested grouping different autoimmune conditions that are triggered by external stimuli as a single syndrome called autoimmune syndrome induced by adjuvants (ASIA). Since the recognition of ASIA syndrom … Oct 12, 2020 · Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. This syndrome is characterized by the appearance of myalgia, myositis, muscle weakness, arthralgia, arthritis, … El síndrome de ASIA es una enfermedad autoinmune e inflamatoria rara y poco común, causada por exponer el organismo a sustancias "extrañas" como la silicona, el hidróxido de aluminio, el mercurio, el aceite mineral y el titanio, por ejemplo. By Treatment Type: Lubricating Drops and Gels: Over-the-counter products designed to provide temporary relief from dry eye symptoms. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA), or Shoenfeld's syndrome, is a hypothesised autoimmune disorder proposed by Israeli immunologist Yehuda Shoenfeld in 2011. It consists in internationally published case reports and newly diagnosed cases of ASIA syndrome reported in the first instance by rheumatologists. Nov 1, 2024 · The Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) has garnered increasing attention within the medical community since it was first introduced by Shoenfeld and Agmon-Levin in 2011 (1). [] and encompasses a cluster of immune mediated diseases, which are likely to develop among genetically predisposed individuals after the exposure to an adjuvant. The disease spectrum is heterogeneous in respect to clinical present … These common denominators were prominent in individuals who developed macrophagic myofasciitis syndrome (MMF), post vaccination phenomenon, Gulf War syndrome (GWS), and siliconosis. Jun 27, 2017 · The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld's syndrome, encompasses several autoimmune conditions/phenomena that are induced following the exposure to substances with adjuvant activity. Jan 1, 2020 · The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld's syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry Clin Rheumatol , 37 ( 2 ) ( 2018 Feb ) , pp. Whether this is association or causation is still under active research 4. Caldeira M, Ferreira AC. 1 Silicone implants have been generally considered relatively inert materials; however, they could generate systemic autoimmune reactions in May 23, 2023 · Introduction: Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) consists of a wide spectrum of symptoms and immunological features that are believed to develop in predisposed individuals after exposure to an adjuvant, including a silicone breast implant (SBI). Jan 1, 2019 · Due to the relative rarity of this condition and its recent identification, as well as to collect data of the disease features, the ASIA syndrome registry was created in 2011. In vaccines and medications, adjuvants act as carriers of molecules Jul 1, 2024 · In clinical practice, physicians can find cases of ASIA syndrome. For a condition to be diagnosed as ASIA, two major criteria or one major criteria alongside two minor ones must be fulfilled [ 10 ]. The search was performed using the key words: therapeutics, treatments, ASIA Syndrome, management, breast implant illness, breast implantation. 483 - 493 Jan 4, 2023 · Introduction. Of which, factors entailing an immune adjuvant activity such as infectious agents, silicone, aluminium salts and others were associated with defined and non-defined immune mediated diseases … Apr 1, 2017 · The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld’s syndrome, encompasses several autoimmune conditions/phenomena that are induced following the exposure May 1, 2013 · The idea of ASIA as a new syndrome developed after some studies on Gulf War syndrome reported that soldiers who had not been deployed to the Gulf area were suffering from symptoms such as severe fatigue, cognitive impairment, myalgias and arthralgias. 2 In contrast, the incidence of GWS was contributed to squalene adjuvant exposure. Keywords: ASIA, genetic predisposition, adjuvants, vaccines, immune system. Methods We searched the Autoimmune syndrome induced by adjuvants (ASIA) is an autoimmune syndrome that characterizes many of these cases. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first defined by Shoenfeld et al in 2011, explaining the mechanism of adverse immune reactions after vaccination using aluminum compounds as an adjuvant. Clin Rheumatol 2018;37(2):483–493. 4. Realizamos la búsqueda con los tér-minos Mesh: therapeutics, treatments, ASIA Syndrome, Management, Jul 1, 2024 · ASIA syndrome classification criteria require validation in various populations before being applied to select patients for clinical studies. Moreover, possible therapies for these patients are difficult–if not impossible–to evaluate because most clinical trials are designed to follow patients with well-defined diseases and involve validated outcomes that often include specific markers. g. May 27, 2025 · Background Rebamipide (RBM) is a novel drug that increases mucin secretion on the ocular surface. Apr 26, 2025 · The ASIA dry eye syndrome treatment market can be segmented based on treatment type, distribution channel, and region. 2. Autoimmune/Inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. ASIA encompasses a spectrum of autoimmune conditions triggered by exposure to adjuvants, substances known to enhance the body's immune response. You should see a doctor if you experience: Persistent and unexplained symptoms following exposure to vaccines, medications, or other potential adjuvants. 1 Post-vaccination phenomena and MMF are thought to mainly develop following the use of aluminum-based adjuvants. Jul 25, 2020 · Considering the sequential development of fibromyalgia and irritable bowel syndrome after the implant of a metal stent containing nickel, in a patient with a previous history of cutaneous nickel allergy, a diagnosis of autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld’s syndrome was discussed for our patient. In this study, we compared one hundred patients with autoimmune/inflammatory syndrome induced by adjuvants (ASIA) due to silicone implant incompatibility syndrome diagnosed in 2014 in Maastricht, the Netherlands, with one hundred historical patients with adjuvant breast disease diagnosed in the Baylor College of Medicine, Houston, USA, between 1985 and 1992. Diagnosis of ASIA is based on major and minor criteria encompassing generalized signs and symptoms such as persistent fatigue, cognitive difficulties, neurological deficits, myalgias/arthralgias, and dry mouth. Different autoimmune . In clinical practice, physicians can find cases of ASIA syndrome. : A systematic review of the literature was carried out using the databases PubMed, SciELO, Scopus and Web of Science, following the PRISMA P and JBI guidelines. Adjuvants are substances incorporated in various medical products to enhance the immune response. 1,2 The role of the adjuvant is to protect antigens from degradation, enabling prolonged exposure to the cells presenting the antigen, which results in greater Oct 5, 2023 · The patient left the hospital on oral steroids (methylprednisone) in high dose, which gradually were tapered to 8 mg methylprednisone daily. 4 From a clinical Abstract. Junto con 3 colaboradores, desarrollamos la búsqueda de la información en las bases de datos PubMed, Scopus, Web of Science y SiELO, con el uso de los siguientes términos Mesh: therapeutics, treatments, therapy, management, treatment outcome, ASIA syndrome, autoimmune inflammatory syndrome induced by adjuvants, breast implant illness Oct 1, 2020 · L’étude bibliographique que nous avons menée sur 126 cas répertoriés selon les critères du syndrome ASIA reste limitée pour prouver cette pathologie et démontrer un lien entre la présence d’un IM en silicone et la survenue d’un syndrome ASIA, en raison du faible nombre de cas publiés (126 en 9 ans) et de la présence de biais. [1] . Dec 31, 2023 · Debido a la heterogeneidad de los datos en estudios previos y las dificultades para diagnosticar ASIA, parece necesario realizar más análisis de la influencia de los adyuvantes en el desarrollo de enfermedades autoinmunes y refinar los criterios de diagnóstico de ASIA, que ahora permiten un diagnóstico demasiado fácil de esta enfermedad. We aimed to summarize the results obtained from the ASIA syndrome registry up to December 2016, in a descriptive analysis … Aug 5, 2024 · Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a group of conditions that some people develop after being exposed to components used in some medications, vaccines, or materials in medical devices, cosmetic elements, and tattoo-inks. Jan 1, 2020 · Adjuvants can be found also in mineral oils and cosmetic products, especially in South American countries. Table 1. cfxsik etjba zwmxlm oikx xppfp innwj zcxb rjtv vfzm kyyp